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The PACE Report - Volume 2, Issue 4

The PACE Report
A Publication of the
Pneumococcal Awareness
Council
of Experts
Volume 2, Issue 4 | October 2009

In This Issue

Note from the Chairs

Dr. Ciro de Quadros
Dr. Orin Levine

Pneumonia is the world’s leading killer of children, claiming 2 million young lives every year. And while vaccines and treatments to prevent and control pneumonia are available, they often don’t reach those that need them the most: children in developing countries.

In this issue, new global disease burden data reinforces the global threat of pneumonia. This November 2 will mark the first-ever World Pneumonia Day created to bring global attention to this neglected yet deadly disease. This day will provide all of us with an important opportunity to take action.

As even more countries consider decisions to include life-saving pneumococcal vaccines in their national immunization programs, World Pneumonia Day provides a perfectly-timed opportunity to demonstrate demand for this safe and effective prevention of one of the leading causes of pneumonia and move governments to act.

As a colleague and valued partner, we urge you to help make World Pneumonia Day a success by getting involved. We invite you to visit www.sabin.org/PACE to access a list of events in your region and download resources to assist your effort. Together, we can make progress toward ensuring that no child dies from this preventable disease.

Thank you,

Ciro de Quadros

Co-Chair

Orin Levine

Co-Chair

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News & Updates

World PneumoniavDay

Get involved in World Pneumonia Day

November 2 will mark the first World Pneumonia Day, a global effort to mobilize activists and encourage donors and governments to pay more attention to – and make an investment in – efforts to combat this disease. This day will provide an important occasion to inform policymakers worldwide about pneumonia’s overwhelming toll and the opportunities for its prevention.

Events will take place around the world to amplify the message of pneumonia’s devastating toll and advocate for its prevention. Organizations and individuals can get involved by signing a pledge, hosting an event, spreading the word, engaging the media, or other creative activities. Learn more about getting involved at www.worldpneumoniaday.org/take-action/overview/.

To learn more about events that are already planned, or to register your own event, visit www.worldpneumoniaday.org/events/. Or, lend your voice for World Pneumonia Day by joining as a partner at www.worldpneumoniaday.org/join-us/.

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Pace Briefing

PACE briefing in the European Parliament encourages European leaders to unite against pneumococcal disease

On October 5, Michael Cashman, MEP joined with PACE to host a parliamentary discussion on the role of the European Union in combating pneumococcal disease. Led by Dr. Ciro de Quadros and Dr. Fred Were of PACE, the discussion called attention to the WHO’s September 2009 data on the global burden of pneumococcal disease and highlighted opportunities for prevention. Michael Cashman, who is also a member of the Parliamentary Committee on Development and Chairman of the Delegation to South Africa, reinforced the role that Members of Parliament can play to prevent needless deaths and help countries achieve MDG4. He encouraged colleagues to recognize World Pneumonia Day on November 2 and to work with their counterparts in developing country governments to make the prevention of pneumococcal disease a priority.

“The European Commission and many EU member states have already made pledges to support immunisation in the world's poorest countries,” said Michael Cashman, MEP. “We can and must do more to prioritise pneumococcal disease within existing health and development efforts and encourage developing country governments to do the same.”

The briefing was part of two days of meetings in which PACE met with members of the European Commission to discuss the need for pneumococcal prevention and encourage further support for research, funding and policy decisions that will advance the disease from unknown global killer to top vaccine-preventable priority.

Read a letter to the editor written by Michael Cashman

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New WHO data underscores global threat of the world’s leading child killer

New World Health Organization data published last month in The Lancet sheds new light on two leading causes of pneumonia – the world’s leading killer of children under age 5 – both globally and within specific countries. The results, which are the first ever available at the country level, are expected to serve as a clarion call to developing countries’ governments to invest in pneumonia prevention programs.

According to the studies, Streptococcus pneumoniae and Haemophilus influenzae type b [Hib] infections take the lives of an estimated 1.2 million children under age 5 each year. Safe and effective vaccines exist to provide protection against both diseases; however, use of Hib vaccine has only recently expanded to low-income countries. Also, the pneumococcal vaccine is not yet included in most national immunization programs in the developing world, where children bear the highest risk for pneumonia and where most pneumonia-related child deaths occur.

"These findings underscore the urgent need for prevention efforts throughout the developing world," said Kate O'Brien, primary author of the pneumococcal study and Associate Professor of International Health at the Johns Hopkins Bloomberg School of Public Health. "The need for vaccination and improved treatment is particularly urgent in Africa and Asia, which together account for 95 percent of all pneumococcal deaths."

To get statistics on pneumococcal disease specific to your region, view the interactive map or read more about this data on PneumoADIP’s Web site.

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Many swine flu deaths linked with bacterial co-infections including pneumococcal disease

Many of the H1N1 swine flu deaths in the United States were also linked to bacterial co-infections including pneumococcal disease. According to the CDC, a study of 77 patients who died of the new pandemic H1N1 virus between May and August this year showed that 29 percent of them had bacterial co-infections. About half of these patients had Streptococcus pneumoniae, which can be prevented with a vaccine.

The study highlights how important it is for people to get vaccinated against pneumococcal disease. “It’s really important for people, especially those at high risk for the serious complications from influenza, to check with their provider when they get their influenza vaccine about being vaccinated against pneumococcus,” said Dr. Matthew Moore of the CDC.

The findings were published September 30 in an early release of the CDC's Morbidity and Mortality Weekly Report. Read the full report on their Web site.

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The Gambia’s pneumococcal vaccine introduction promises to significantly reduce child mortality

The Gambia introduced pneumococcal vaccine into its national immunization program on August 19, becoming the third country in Africa to take this step. Introduction of the pneumococcal vaccine follows introductions in Rwanda and South Africa in April. The introduction was made possible by a donation of PCV-7 by Wyeth through the GAVI Alliance.

“It is particularly rewarding to see Gambian children now benefiting from these scientific advances and from the opportunities for access provided by the GAVI Alliance,” said Dr. Orin Levine, Executive Director of the PneumoADIP at Johns Hopkins Bloomberg School of Public Health. “No other country has contributed as much to our understanding of the burden of pneumococcal disease and the value of pneumococcal vaccines as The Gambia.”

Read more on The Gambia’s introduction on the GAVI Alliance’s Web site.

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New pneumococcal vaccination cost-effectiveness model launched

A new interactive Pneumococcal Conjugate Vaccination Policy Model, which helps to project health benefits, costs, and cost effectiveness of childhood pneumococcal conjugate vaccine based on available evidence and research, was launched this year by the University of Medicine and Dentistry of New Jersey and Johns Hopkins Bloomberg School of Public Health. The model addresses the need for streamlined cost effectiveness analysis tools to assist decision makers in understanding the economic and health benefits associated with vaccine introductions.

The model was developed through an expert panel process in order to reach consensus on the key assumptions about epidemiology, vaccine efficacy, costs, and model outputs projecting the cost-effectiveness of pneumococcal conjugate vaccine. Members of the panel were chosen for their expertise in pneumococcal epidemiology, vaccine-related health economics, public health, and/or preventive medicine, particularly in GAVI-eligible settings. Learn more about the model or log in and test the model out on the PneumoADIP Web site.

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Pneumococcal vaccine introductions in low-income countries deliver on promise of vaccines

Low-income countries deliver on promise of vaccines

The recent introduction of pneumococcal conjugate vaccines in The Gambia – the second low-income country to introduce pneumococcal conjugate vaccines – solidifies a new era in vaccine introduction. Currently nine countries are already approved by GAVI for pneumococcal conjugate vaccine funding and many additional countries have expressed their interest in GAVI funding. With the realization of the introduction of pneumococcal vaccine in all GAVI-eligible countries, 7 million lives can be saved by 2030.

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PACE Members

PACE welcomes three new members

PACE is proud to welcome three new members to the Council, Dr. Najwa Khuri-Bulos, Head of the Division of Infectious Disease at Jordan University Hospital; Dr. Shabir Madhi, Chair of the Department of Science and Technology at the National Research Foundation of South Africa; and Dr. Yong-Hong Yang, Professor of Pediatrics, Beijing Children’s Hospital. With the addition of these distinguished members, PACE is represented by 21 members in 17 countries. For a full list of PACE members, click here.

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Dr. Saha

Spotlight on Dr. Samir Saha

Professor and Head
Department of Microbiology, Bangladesh Institute of Child Health
Dhaka Shishu Hospital
Executive Director
Child Health Research Foundation
Bangladesh

Dr. Samir Saha is a well-respected researcher and a fierce advocate for pneumococcal disease prevention. For more than a decade, Dr. Saha’s research group has conducted surveillance of invasive childhood diseases in Bangladesh and has generated data on Streptococcus pneumoniae and Haemophilus influenzae type b. This research has contributed to a better understanding of the burden, drug resistance and epidemiology of childhood diseases like pneumonia, meningitis and typhoid.

Dr. Saha’s research and advocacy has had a major impact on public health policy issues in Bangladesh and the surrounding region. His group’s findings on Haemophilius influenzae type b, coupled with direct advocacy by Dr. Saha, played a significant role in convincing the policymakers of Bangladesh to make an evidence-based decision to include the Hib vaccine in its national immunization program. Working with Parliament members, Dr. Saha worked tirelessly to get the issue of pneumonia – and its devastating burden and need for prevention – on the floor of the Bangladesh Parliament, resulting in their recent decision to apply for GAVI funding for pneumococcal vaccines.

To commemorate the first ever World Pneumonia Day, Dr. Saha is working with PACE to coordinate two days of events and activities in Dhaka, Bangladesh. These events will serve to highlight the issue of pneumonia among policy makers and the general public.

“As a researcher in this region of the world, I see the effects of pneumonia everywhere. Yet awareness remains low and advocacy remains extremely important in moving governments to take action against deadly diseases,” said Dr. Saha. “As scientists we have the data and evidence to make the case for pneumococcal disease prevention, and we must continue to get this message heard by policy makers who often do not understand pneumonia’s full impact.”

Dr. Saha currently serves as the Professor and Head of the Department of Microbiology at the Bangladesh Institute of Child Health at Dhaka Shishu Hospital in Dhaka, Bangladesh. In addition, Dr. Saha is an associate of the Department of International Health of Johns Hopkins University, Maryland, USA, and the Executive Director of Child Health Research Foundation, Bangladesh. He has published more than 50 papers in peer-reviewed journals, mostly relating to childhood pneumonia and meningitis.

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PACE Partners

WSPID Logo

Spotlight on the World Society for Pediatric and Infectious Diseases (WSPID)

The World Society for Pediatric Infectious Diseases (WSPID) is a global confederation of Pediatric Infectious Diseases (PID) societies that aspires to engage societies in exchange of information and knowledge in order to foster collaboration among PID specialists from all over the world.

From November 18 to 22, WSPID will convene the 6th World Congress of the World Society of Pediatrics and Infectious Diseases in Buenos Aires, Argentina. The conference will bring together members of national and regional organizations in pediatric infectious diseases for an international congress, during which data can be exchanged and colleagues can interact. New evidence on the effectiveness of pneumococcal conjugate vaccines, developments on the expanded spectrum of these vaccines and the latest news on the implementation of pneumococcal vaccines worldwide will be discussed. Regional societies from Europe, North America, Latin America, Asia, Australasia and Africa are participating in the World Congress of WSPID.

During the conference, PACE will convene an advocacy luncheon that serves to educate participants on effective advocacy strategy and invite participation in the discussion of current evidence-based advocacy efforts to secure commitments to prevent pneumococcal disease.

“WSPID is pleased to partner with PACE and to help underscore the importance of evidence-based advocacy in achieving disease prevention and saving lives,” said PACE member and WSPID president Ron Dagan. “For pneumococcal disease in particular, there has never been a better opportunity for countries to invest in prevention, and it remains up to those of us in the global health community to reinforce that.”

To learn more about WSPID and its current activities, visit www.wspid.com.

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World Pneumonia Day Banners

World Pneumonia Day banners

World Pneumonia Day banners available for download

World Pneumonia Day banners are available in 3’x8’, 8’x4’ and 10’x6’ sizes. Download and print them to display in your lobby, post in community gathering places or display at your event to let your community know about World Pneumonia Day. Banners are available at www.sabin.org/pace/world_pneumonia_day/banners.

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Upcoming Events

October 26

PACE Media Briefing
Johannesburg, South Africa

November 2

First Annual World Pneumonia Day

November 1-2

PACE Rally, Media Briefing and Symposium
Dhaka, Bangladesh

November 19

PACE Advocacy Panel at the World Society of Pediatric Infectious Diseases (WSPID)
Buenos Aires, Argentina

November 21

Run for Survival
Nairobi, Kenya

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About PACE

Sabin Vaccine Institute

A project of the Sabin Vaccine Institute, the Pneumococcal Awareness Council of Experts (PACE) is comprised of leading global experts in infectious diseases and vaccines. The Council raises awareness among policy makers and aims to secure global commitments to prevent pneumococcal disease — a leading infectious killer of children and adults worldwide — working through collaboration and partnership with countries, NGOs, academia and industry to achieve its goals. For more information about PACE and the Global Call to Action, please visit www.sabin.org/PACE.

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Awareness. Action. Prevention.

PACE is a project of the Sabin Vaccine Institute

2000 Pennsylvania Avenue, NW . Suite 7100 . Washington, DC . 20006 . + 1.202.842.5025 phone . + 1.202.842.7689 fax . www.sabin.org/PACE