Project Status

In collaboration with researchers at the James Cook University and The George Washington University, a promising new antigen, Sm-TSP-2 (Schistosoma mansoni Tetraspanin-2), was selected for development as a schistosomiasis vaccine. Then at Texas Children's Hospital and Baylor College of Medicine, Sabin and its partners developed the process for manufacture of the vaccine under cGMP, and was followed by technology transfer to Sabin's manufacturing partner, Aeras.

Schistosomiasis Vaccine

For more than a decade, the Sabin PDP collaborated with partners from across the globe to develop new, low-cost vaccines that have little commercial market for diseases that primarily impact the world's poorest populations, including humanhookworm, schistosomiasis, onchocerciasis, SARS and Chagas disease. Baylor College of Medicine and Texas Children’s Hospital Center for Vaccine Development continue this research as of May 2017.

Capabilities

With over a decade of experience, Sabin PDP has produced a well-rounded model that serves as a blueprint for the development of safe and effective vaccines against vaccine preventable and neglected tropical diseases. Existing capabilities include:

Product Development: Established the infrastructure to engage in antigen discovery, rapid development of scalable manufacturing processes (process development), quality control, preclinical and clinical immunology and stability testing.

Neglected tropical diseases (NTDs) were on the agenda this week at the Sixty-fifth session of the World Health Assembly (WHA) in Geneva, Switzerland.
 
A major milestone was reached when the WHA today approved a new resolution on elimination of schistosomiasis.

Reversing the World’s Neglect of Easily Cured Tropical Diseases

May 18, 2012 | Pacific Standard

Ahead of this weekend’s G8 Summit, Dr. Peter Hotez wrote an op-ed for Pacific Standard calling on G8 leaders to focus on NTD treatment and control as a cost-effective method to improve global health.

Reversing the World’s Neglect of Easily Cured Tropical Diseases

Dr. Peter Hotez

Pacific Standard

Drs. Mistry and de Quadros contribute to Huffington Post G8 series

May 15, 2012 | Huffington Post

For the past week, the Sabin Vaccine Institute and the Global Network for Neglected Tropical Diseases have been working with a group of organizations to raise awareness of specific issues - such as global health, nutrition, the environment and corruption – in advance of the G8.

Huffington Post

Introduction

Schistosomiasis, also known as bilharzia or “snail fever”, is a parasitic disease carried by fresh water snails infected with one of the five varieties of the parasite Schistosoma.

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