New typhoid conjugate vaccines offer important advantages over prior vaccines, including the ability to protect young children, longer lasting protection, and the potential to be a part of routine immunization of infants.

Investigators from the Aga Khan University (AKU) are actively investigating a large outbreak of typhoid fever bacteria that are resistant to ceftriaxone, an antibiotic commonly used by physicians to treat this infection.

This is Gul Rahim’s story of typhoid, as told to Attaullah Baig of Aga Khan University Hospital on January 7, 2017, and translated into English. The interview was conducted in Urdu and has been edited for clarity and length.

More than 300 researchers from 45 countries gathered in Kampala, Uganda in early April for the 10th International Conference on Typhoid and Other Invasive Salmonelloses.

For years, little was known of the typhoid burden in Africa, even though outbreaks of multi-drug resistant typhoid is becoming increasingly common. This lack of information spurred the Bill and Melinda Gates Foundation to fund the Typhoid Fever Surveillance in Africa Program (TSAP) through the International Vaccine Institute, a first-of-its-kind study established to shed light on true extent of the typhoid burden and multi-drug resistance distribution on the continent. The results from the TSAP, recently published in the Lancet Global Health, represent the most comprehensive and rigorous analysis of typhoid in Africa and could change our understanding of the disease burden across the continent.

Diseases

The Sabin Vaccine Institute works to extend the benefits of immunization to all people by enabling vaccine access and uptake. Sabin brings together national government officials, policy makers, immunization specialists, researchers and advocates to supply decision makers with the data and expertise they need to make evidence-based decisions on vaccines. Our work includes a number of diseases, including:

Typhoid Research & Advocacy

One-third of the world’s population is at risk of contracting typhoid, a systemic bacterial infection spread through contaminated food and water that kills an estimated 220,000 people each year, primarily children in low-income countries. Caused by the bacteria Salmonella enterica serotype Typhi (S. Typhi), typhoid is an acute illness that is often misdiagnosed because its symptoms – prolonged fever, headache, nausea, constipation, loss of appetite and diarrhea – are so common.

Global Consensus

Working together to shape global health solutions is more important than ever. Sabin seeks to extend the benefits of immunization to everyone by bringing together representatives from across the private and public sectors to identify key challenges facing global immunization and help establish best practices and recommendations to overcome them.

Introduction & Expansion

Over the last decade, many new vaccines have been developed, but the promise of these vaccines is only fulfilled when they are administered around the world. To deliver health to as many people as possible, countries need accurate, high-quality data to ensure their resources are used effectively.

Sabin brings together national government officials, policy makers, immunization specialists, researchers and advocates to supply decision makers with the data and expertise they need to make evidence-based decisions on vaccines.

Overseas travelers can sometimes bring back unwanted souvenirs — with tragic consequences. A localized outbreak of typhoid in Auckland, New Zealand has taken the life of one patient and affected 20 others. Public health authorities believe that a traveler to a typhoid-endemic country may have unknowingly contracted the disease and carried it back into the country.

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