About Hookworm

Hookworm is an intestinal parasite most commonly found in tropical and sub-tropical climates of Africa, Asia and Latin America.  Hookworm, one of three members of a family of parasites known as the soil-transmitted helminths (STHs), are half-inch long worms that attach themselves to the intestinal wall and feed on human blood. Left untreated, hookworm causes severe intestinal blood loss leading to iron-deficiency anemia and protein malnutrition, particularly in pregnant women and children.

Project Status

 
The Human Hookworm Vaccine Initiative (HHVI) has identified and produced several candidates for potential use as a vaccine. HHVI is focused on developing and testing a vaccine to prevent moderate to severe hookworm infection in children younger than 10 years old living in endemic areas.

Capabilities

With over a decade of experience, Sabin PDP has produced a well-rounded model that serves as a blueprint for the development of safe and effective vaccines against vaccine preventable and neglected tropical diseases. Existing capabilities include:

Product Development: Established the infrastructure to engage in antigen discovery, rapid development of scalable manufacturing processes (process development), quality control, preclinical and clinical immunology and stability testing.

The recent West Nile Virus outbreaks in Texas and across the United States have called attention to the strong links between tropical diseases and poverty, both in the United States and abroad. In an editorial published in the Sunday, September 2 edition of the Houston Chronicle, Dr. Hotez and his co-author, Dr. Kristy Murray of Baylor College of Medicine, called for more disease surveillance, education for healthcare providers and greater engagement by product development partnerships such as the Sabin PDP to respond to these urgent public health issues:

Chagas Disease/Leishmaniasis

For more than a decade, the Sabin PDP collaborated with partners from across the globe to develop new, low-cost vaccines that have little commercial market for diseases that primarily impact the world's poorest populations, including humanhookworm, schistosomiasis, onchocerciasis, SARS and Chagas disease. Baylor College of Medicine and Texas Children’s Hospital Center for Vaccine Development continue this research as of May 2017.

Human Hookworm Vaccine

For more than a decade, the Sabin PDP collaborated with partners from across the globe to develop new, low-cost vaccines that have little commercial market for diseases that primarily impact the world's poorest populations, including humanhookworm, schistosomiasis, onchocerciasis, SARS and Chagas disease. Baylor College of Medicine and Texas Children’s Hospital Center for Vaccine Development continue this research as of May 2017.

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