Partners

The development of a successful vaccine is a significant undertaking that takes years to achieve. The Sabin Vaccine Institute Product Development Partnership (PDP) is internationally recognized for its development of safe, effective vaccines against tropical infections including human hookworm, schistosomiasis, Chagas disease, leishmaniasis and SARS. Sabin PDP esteemed partners include:

Capabilities

With over a decade of experience, Sabin PDP has produced a well-rounded model that serves as a blueprint for the development of safe and effective vaccines against vaccine preventable and neglected tropical diseases. Existing capabilities include:

Product Development: Established the infrastructure to engage in antigen discovery, rapid development of scalable manufacturing processes (process development), quality control, preclinical and clinical immunology and stability testing.

The recent West Nile Virus outbreaks in Texas and across the United States have called attention to the strong links between tropical diseases and poverty, both in the United States and abroad. In an editorial published in the Sunday, September 2 edition of the Houston Chronicle, Dr. Hotez and his co-author, Dr. Kristy Murray of Baylor College of Medicine, called for more disease surveillance, education for healthcare providers and greater engagement by product development partnerships such as the Sabin PDP to respond to these urgent public health issues:

Chagas Disease/Leishmaniasis

The Sabin PDP has initiated development for a new therapeutic vaccine for Chagas disease that will be undertaken with partners in Mexico, where between two and six million people are infected with this leading cause of poverty in Latin America. Current efforts focus on the development of two vaccine candidate antigens that will ultimately comprise the first therapeutic vaccine for Chagas disease.

Human Hookworm Vaccine

The Sabin Vaccine Institute PDP works on developing vaccines for the more than 700 million people suffering from hookworm in the world today. Established in 2000 with funding from the Bill & Melinda Gates Foundation, the Sabin PDP (originally the Human Hookworm Vaccine Initiative) is the first and only PDP in the world developing a vaccine for human hookworm infection.

What We Do

The Sabin PDP is focused on the development of sustainable and cost-effective vaccines for preventing widespread neglected tropical diseases (NTDs), including hookworm, schistosomiasis, Chagas disease and leishmaniasis.

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