For more than a decade, the Sabin PDP collaborated with partners from across the globe to develop new, low-cost vaccines that have little commercial market for diseases that primarily impact the world's poorest populations, including humanhookworm, schistosomiasis, onchocerciasis, SARS and Chagas disease. Baylor College of Medicine and Texas Children’s Hospital Center for Vaccine Development continue this research as of May 2017.

The Sabin Vaccine Institute PDP works on developing vaccines for the estimated 440 million people suffering from hookworm in the world today. Established in 2000 with funding from the Bill & Melinda Gates Foundation, the Sabin PDP (originally the Human Hookworm Vaccine Initiative) is the first and only PDP in the world developing a vaccine for human hookworm infection.