About Hookworm

Hookworm is an intestinal parasite most commonly found in tropical and sub-tropical climates of Africa, Asia and Latin America.  Hookworm, one of three members of a family of parasites known as the soil-transmitted helminths (STHs), are half-inch long worms that attach themselves to the intestinal wall and feed on human blood. Left untreated, hookworm causes severe intestinal blood loss leading to iron-deficiency anemia and protein malnutrition, particularly in pregnant women and children.

Project Status

The Human Hookworm Vaccine Initiative (HHVI) has identified and produced several candidates for potential use as a vaccine. HHVI is focused on developing and testing a vaccine to prevent moderate to severe hookworm infection in children younger than 10 years old living in endemic areas.


Sabin’s diverse partnerships are important to achieving the organization’s mission. The Sabin Vaccine Institute Product Development Partnership (Sabin PDP) leverages the expertise of partners in the academic, public and private sectors and promotes open-source research that focuses on capacity building, infrastructure development and knowledge sharing. To advance product development, we are working with institutions in Europe, Brazil, Malaysia and Mexico to expand product development and manufacturing capabilities to develop new vaccines.


With over a decade of experience, Sabin PDP has produced a well-rounded model that serves as a blueprint for the development of safe and effective vaccines against vaccine preventable and neglected tropical diseases. Existing capabilities include:

Product Development: Established the infrastructure to engage in antigen discovery, rapid development of scalable manufacturing processes (process development), quality control, preclinical and clinical immunology and stability testing.

Human Hookworm Vaccine

The Sabin Vaccine Institute PDP works on developing vaccines for the estimated 440 million people suffering from hookworm in the world today. Established in 2000 with funding from the Bill & Melinda Gates Foundation, the Sabin PDP (originally the Human Hookworm Vaccine Initiative) is the first and only PDP in the world developing a vaccine for human hookworm infection.

The Human Hookworm Vaccine Prospectus

What We Do

The Sabin PDP is focused on the development of sustainable and cost-effective vaccines for preventing widespread neglected tropical diseases (NTDs), including hookworm, schistosomiasis, Chagas disease and leishmaniasis.

Vaccine Development

An essential element of the Sabin Vaccine Institute’s mission to reduce human suffering caused by vaccine preventable and neglected tropical diseases (NTDs) is the Sabin Vaccine Institute Product Development Partnership (Sabin PDP), an internationally recognized PDP focused on creating safe, effective, low-cost vaccines for tropical infections in developing countries.

The latest from Dr. Peter Hotez in PLoS Neglected Tropical Diseases

June 27, 2012 | PLoS Neglected Tropical Diseases

Neglected Tropical Diseases as Hidden Causes of Cardiovascular Disease

Yasmin Moolani, Gene Bukhman, Peter J. Hotez

An important component of the burden of cardiovascular disease in low- and middle-income countries may be attributed to the neglected tropical diseases.


Reversing the World’s Neglect of Easily Cured Tropical Diseases

May 18, 2012 | Pacific Standard

Ahead of this weekend’s G8 Summit, Dr. Peter Hotez wrote an op-ed for Pacific Standard calling on G8 leaders to focus on NTD treatment and control as a cost-effective method to improve global health.

Reversing the World’s Neglect of Easily Cured Tropical Diseases

Dr. Peter Hotez

Pacific Standard


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