The burden of pneumococcal disease in older children and adults in Latin America and the Caribbean
Streptococcus pneumoniae remains an important cause of pneumonia and invasive bacterial disease, primarily meningitis and sepsis. The greatest burden of disease occurs in low-and middle-income countries, and the risk of serious pneumococcal disease peaks at the extreme ages of life. Young children are at highest risk, but older adults and people with immuno-compromising conditions also suffer high rates of pneumococcal disease. The burden of pneumococcal disease among children less than 5 years of age has been well characterized, both globally and in the region of Latin America and the Caribbean (LAC). However, fewer data are available on the incidence and mortality of pneumococcal disease among older children and adults, particularly in low- and middle- income countries.
We explored the epidemiology of pneumococcal disease among persons ≥5 years in the region through a systematic literature review and analyses of regional laboratory-based surveillance data.