Disease Focus Areas


The COVID-19 pandemic has altered the global health and vaccine landscapes forever. It brought inequalities to the surface and spurred a new rise in misinformation about vaccines.

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Sabin is working to harness real-time, critical insights from the pandemic to improve how vaccines are made and delivered, with a focus on advancing countries’ ability to access, develop and distribute vaccines effectively.

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COVID-19 Vaccine Vials

Dose-Optimizing COVID-19 Vaccine Clinical Trial

The Sabin Vaccine Institute was awarded up to $6.3 million from the Coalition for Epidemic Preparedness Innovations (CEPI) for a clinical trial to evaluate the immunogenicity and safety of lower, fractional doses of registered COVID-19 vaccines used as a booster dose. This dose optimizing trial will allow us to understand if smaller doses of COVID-19 vaccines generate similar immune responses to full doses. It will also provide key information as to whether lower doses may have fewer side effects, potentially increasing vaccine acceptance.

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“The only way to end this pandemic is to ensure that everyone, everywhere has access to vaccines. That was Dr. Sabin’s goal during his lifetime, and it’s the goal now of the Sabin Vaccine Institute and this research.”

Amy Finan

Chief Executive Officer