Our Programs

Vaccine Research & Development

About Our Vaccine R&D Program

Our R&D strategy focuses on developing new vaccines and improving existing vaccines that target diseases primarily impacting the world’s most vulnerable populations, but have little commercial value.

Current Vaccine Program

Building on non-clinical and clinical research performed previously by the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center and GSK, we are advancing vaccine candidates against Marburg and Ebola Sudan viruses using the ChAd3 platform.

Marburg and Ebola Sudan are among the world’s deadliest viruses, causing hemorrhagic fever with subsequent death in an average of 50 percent of cases. A closely related strain, Ebola Zaire, has caused more than 2,200 deaths from 2018-2020 in the Democratic Republic of Congo (DRC), leading the World Health Organization (WHO) to declare it a Public Health Emergency of International Concern. With Marburg and Ebola Sudan’s own history of outbreaks and their potential for future devastating outbreaks, preventative measures are essential to protecting people against these emerging infectious diseases.

While there are two approved vaccines for Ebola Zaire, no licensed vaccines exist to protect against Marburg or Ebola Sudan viruses.

See our trials on clinicaltrials.gov


Marburg - Completed Phase 1b

Sabin’s Marburg vaccine (ChAd3-MARV) has completed a Phase 1 clinical trial in the United States and we are planning a Phase 2 trial.

Ebola Sudan - Completed Phase 1b

Sabin’s Ebola Sudan vaccine (ChAd3-SUDV) has been evaluated in Phase 1 trial in the United States. We are currently planning a Phase 2 trial.

Vaccine Development Using the ChAd3 Platform

In August 2019, Sabin announced exclusive agreements with GSK for Sabin to advance the development of the prophylactic candidate vaccines against the deadly Ebola Zaire, Ebola Sudan and Marburg virus. Under the agreements between GSK and Sabin, Sabin exclusively licensed the technology for all three candidate vaccines and acquired certain patent rights specific to these vaccines. The three candidate vaccines were initially developed collaboratively by the U.S. National Institutes of Health and Okairos, which was acquired by GSK in 2013. The candidate vaccines, based on GSK’s proprietary ChAd3 platform, were further developed by GSK, including the Phase II development for the Ebola Zaire vaccine.

In September 2019, U.S. Health and Human Services’ Biomedical Advanced Research and Development Authority (BARDA) awarded Sabin a development contract (75A50119C00055), valued up to US$128 million to develop the Marburg and Ebola Sudan vaccines. To date, BARDA has provided US$76 million in funding to further continue pre-clinical efficacy and safety studies, clinical trials in Africa and vaccine manufacturing processes to ensure quality and safety.

Promising Clinical Trials for the ChAd3 Platform


The ChAd3-based vaccines against Ebola Zaire, Ebola Sudan, and Marburg viruses have demonstrated a strong safety profile and encouraging immunogenicity results after being administered to more than 5,000 adults and 600 children, in 13 different clinical trials to date.